Research in Briefs
High-throughput analysis reveals that retinal genes are influenced by a high-fat diet alone, independent of gut bacteria, in ways that increase susceptibility to macular degeneration.
A genetic mutation is found to impair lipid metabolism and function of microglia, key defensive players in the brain.
Age-related changes make it harder for eye cells to come up with the energy needed for vision – and that deficit is widely thought to play a role in AMD.
Researchers discover 10 new gene variants that increase the risk of Alzheimer’s disease (AD), including some on rare genes that were never before linked to AD.
Brain tissue grown in a dish called an “organoid,” was used to study how genetic mutations contribute to FTD.
Gene found to regulate tissue responsible for draining fluid from the eye.
BrightFocus-funded researchers have proposed a new way to treat Alzheimer’s, by clearing toxic tau from the connections, or synapses, between brain cells.
BrightFocus is funding early science behind a promising new technology– a wearable device that provides a very early prediction of Alzheimer’s onset.
Researchers uncover a potential association between an APOE genetic variant and changes in brain metabolism leading to increased risk of Alzheimer’s disease and cognitive impairment.
Age-related macular degeneration is thought to begin with a combination of genetic and environmental risk factors that damage retinal cells and lead to the formation of small droplets that may be precursors to drusen. In early studies drugs that inhibit cholesterol help prevent this.
