Expert

Medications that May Adversely Affect Glaucoma

University of California, San Francisco, UCSF Medical Center
A physician reading a label on a medication bottle.
Many different drugs have the potential to elevate eye pressure and increase the risk of developing glaucoma. This article explores the classes of medications that may affect the open-angle and angle-closure forms of glaucoma.

Important: Do not stop taking prescription medications without first consulting with your doctors.

Narrow Angles and Angle-Closure Glaucoma

What is Angle-Closure Glaucoma? 

Angle-closure glaucoma, the second most common type, is a largely inherited disorder caused by a too-narrow angle in the passageway where aqueous fluid would normally drain. This type of glaucoma may occur in two ways:

  • The chronic type progresses slowly and, like open-angle glaucoma, can result in optic nerve damage. There are no symptoms until there is an apparent loss off peripheral vision. Treatment includes medication and laser therapy.

  • The acute (also called closed-angle) type begins suddenly when the normal flow of aqueous humor between the iris and lens is blocked. The symptoms include, severe eye pain, nausea and vomiting, sudden onset of visual disturbance, often in low light. blurred vision, halos around lights, and reddening of the eye. This condition is a medical emergency and must be treated immediately. The initial treatment steps are to break the attack, which is accomplished using a combination of eye pressure lowering medications and laser iridotomy. Without treatment, blindness can result in one or two days.

Most medications that could adversely affect glaucoma, or increase the chance of developing glaucoma, have the potential to narrow the drainage angle of your eye, called the trabecular meshwork. This would prevent eye fluid from exiting properly resulting in high eye pressure. The “angle” that is being referred to is the angle between the iris, which makes up the colored part of your eye, and the cornea, which is the clear window front part of your eye.

Therefore, if you have a known history of narrow angles or the condition known as angle-closure glaucoma, you should definitely call your ophthalmologist prior to using any medication that has a glaucoma warning.

Factors that Increase Rrisk for  Developing Medication-Induced Angle Closure

  • advanced age
  • female gender
  • hyperopia (farsightedness)
  • Asian ethnicity
  • positive family history of angle-closure glaucoma
  • known preexisting narrow angles

Medications to Discuss with Your Doctor if You have Angle-Closure Glaucoma

Anticholinergics

Medications that have anticholinergic properties can adversely affect patients with narrow angles. Anticholenergic means that these drugs block the action of acetylcholine, a chemical messenger that transmits signals from one nerve cell to another nerve cell, muscle cell, or gland cell, for example.

Medications that have anticholinergic properties are used to treat the following medical conditions:

  1. Asthma and COPD
    Asthma and COPD (chronic obstructive pulmonary disease) medications include drugs such as Atrovent (ipratroprium bromide) or Spiriva (tiotropium bromide), and may be associated with angle-closure glaucoma attacks.

  2. Incontinence and Overactive Bladder Medications
    This class of medications includes Detrol (tolterodine) and Ditropan (oxybutynin)

  3. Gastrointestinal Issues
    Medications such as Tagamet (cimetidine) and Zantac (ranitidine) are weak anticholinergics that may lead to angle-closure.

  4. Muscle Spasms
    Medications such as Norflex (orphenadrine) and Artane (trihexyphenidyl) have been associated with angle closure.

  5. Depression
    Many medications used for depression can have adverse effects in patients with narrow angles. These include selective serotonin reuptake inhibitors (SSRIs) such as Prozac (fluoxetine) and Paxil (paroxetine). Tricyclic antidepressants such as Elavil (amitryptiline) and Tofranil (imipramine) may also have some anticholinergic activity and thus should be used in caution in patients with narrow angles.

  6. Allergies
    Anti-allergy over-the-counter drugs that contain diphenhydramine put patients with narrow angles at risk.

  7. Nausea
    Some medications used to treat nausea have anticholinergic effects, such as Phenergan (promethazine).

  8. Anxiety
    One example is Vistaril (hydroxyzine), a medication that reduces anxiety, and can have strong anticholinergic effects, increasing the risk for angle closure.

Ephidrine-Containing Drugs

Ephedrine can result in acute angle-closure glaucoma attacks in patients with preexisting narrow angles. Some cold medications contain ephedrine for managing congestion.

Sulfonamide-Containing Drugs

There are certain drugs that can cause angle closure in some people, often in both eyes. This is because patients are likely to experience an allergic reaction to the sulfa drug. Examples of sulfonamide-containing drugs, include Topamax (topiramate), Diamox (acetazolamide), Qualaquin (quinine), Sumycin (tetracycline), and Bactrim (trimethoprim/sulfamethoxazole) .

Oral Steroids

Oral steroids can help to reduce inflammation and to reduce the activity of the immune system. This class of medication can affect eye pressure in people that have open-angle glaucoma, but can also raise eye pressure in those with the angle-closure form of the disease. See below for a list of some of the conditions that are treated using oral steroids.

Open-Angle Glaucoma

What is Open-Angle Glaucoma?

Primary open-angle glaucoma is the most common type and accounts for 70-90 percent of all cases. Often there are no noticeable symptoms at early stages, and high intraocular pressure (IOP) is the most significant risk factor or indication that you are developing glaucoma.

This is a chronic, slowly-progressing condition. Many factors, including age, structural defects, damage to the trabecular meshwork and/or other drainage systems in the eye, aqueous humor overproduction, or blockages may be responsible for a rise in IOP. Treatment for open-angle glaucoma includes medication, laser surgery, and incisional surgery..

Medications to Discuss with Your Doctor if You have Open-Angle Glaucoma

Oral Steroids

As mentioned above, oral steroids can help to reduce inflammation and to reduce the activity of the immune system. This class of medication is used for many conditions, including:

  1. Autoimmune diseases (lupus, autoimmune hepatitis)

  2. Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis)

  3. Joint and muscle diseases (rheumatoid arthritis, polymyalgia rheumatic)

  4. Allergies and asthma

Short courses (1 to 2 weeks, for example) and lower doses of oral steroids decrease the risk of increased eye pressure. Other side effects in the eye, beyond increased pressure, include cataracts.

Not every person develops elevated eye pressures when taking oral steroids. Your risk is higher, however, if you have open-angle glaucoma, so if you are undergoing treatment for glaucoma and have recently been diagnosed with a condition that requires more chronic use of oral steroids, you should discuss this with your ophthalmologist. He or she may want to monitor you more closely while you are on steroid treatment. And, of course, topical steroid eye drops can increase eye pressure, but if you are using these medications, you should already be under the care of an eye care provider.

Talk to Your Doctor or Pharmacist

There are many other medications than can increase the risk of glaucoma in addition to the ones mentioned in this article, so it is always wise to talk with your pharmacist or your eye doctor about your medication regimen. Most pharmacies will give you the opportunity to speak with a pharmacist about your medications. You should mention that you have glaucoma and ask whether there are any potential issues.

Most medications that can adversely affect glaucoma or put you at risk of developing glaucoma apply to persons who have narrow angles or angle-closure glaucoma. If you do not know your status, please consult with your eye doctor. If you do have narrow angles and must take medications that could cause further narrowing, a laser peripheral iridotomy could be very helpful in preventing an acute angle-closure attack.

Resources:

This content was first posted on: March 14, 2017

The information provided here is a public service of the BrightFocus Foundation and should not in any way substitute for personalized advice of a qualified healthcare professional; it is not intended to constitute medical advice. Please consult your physician for personalized medical advice. BrightFocus Foundation does not endorse any medical product, therapy, or resources mentioned or listed in this article. All medications and supplements should only be taken under medical supervision. Also, although we make every effort to keep the medical information on our website updated, we cannot guarantee that the posted information reflects the most up-to-date research.

These articles do not imply an endorsement of BrightFocus by the author or their institution, nor do they imply an endorsement of the institution or author by BrightFocus.

Some of the content may be adapted from other sources, which will be clearly identified within the article.

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