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Lutein and Zeaxanthin for Protection against Macular Degeneration

Scheie Eye Institute, University of Pennsylvania
A person tossing assorted vegetables (that contain lutein and zeaxanthin) in a wok.
Age-related macular degeneration is the leading cause of legal blindness in older Americans. Therefore, it’s important to decrease the risk as much as possible. This article discusses lutein and zeaxanthin, micronutrients found in many fruits and vegetables, and how they may help to protect the macula.

The age-related eye disease studies (AREDS) showed that supplementation with certain micronutrients reduces the risk of progression from intermediate age-related macular degeneration to the advanced stage by 25 percent. Also, a diet rich in fruits and vegetables, as well as twice-weekly meals of fat-rich fish like salmon, sardines, tuna, or mackerel is associated with decreased risk.

There have been two AREDS studies. AREDS1 showed that 15 milligrams (mg) of beta carotene, 500 mg of vitamin C, 400 IU of vitamin E, 80 mg of zinc oxide, and 2 mg of cupric oxide reduced the risk of disease progression. AREDS2 tested the substitution of 10 mg of lutein and 2 mg of zeaxanthin for beta carotene. This substitution did not diminish the effectiveness of the formula, and was especially helpful for people who had low level consumption of lutein and zeaxanthin in their diet.

Lutein and Zeaxanthin

  • Lutein, and zeaxanthin are specific types of micronutrients from plants), which are structurally related to vitamin A.

  • Our bodies do not make these micronutrients; however, plants make them.

  • When we eat lutein and zeaxanthin, they are transported to the retina, where they are thought to protect against light-induced damage.


Beta carotene, lutein, and zeaxanthin are all specific types of phytochemicals (micronutrients from plants) called carotenoids, which are structurally related to vitamin A. Our bodies do not make these micronutrients; however, plants make them, in part, to serve as antioxidants* that protect them from potentially harmful sunlight. When we eat lutein and zeaxanthin, they are transported to the retina, where they are thought to protect against light-induced damage. There’s normally enough lutein and zeaxanthin in the macula, the central part of the retina, to turn this part yellow. In fact, the full name of the macula is macula lutea, means yellow spot. It has been shown that taking lutein and zeaxanthin supplements leads to increased levels of these antioxidants in the macula.

Vision Foods

Foods such as egg yolk (go easy due to cholesterol), yellow corn, orange or yellow peppers, kale, broccoli, spinach, kiwi, grapes, zucchini, and squash have high levels of lutein and/or zeaxanthin.

Foods with the highest levels of lutein and Zeaxanthin


For people without macular degeneration, the above foods are a good way to decrease the risk of AMD. For those with early macular degeneration, the AREDS2 vitamins are recommended. AREDS1 formula vitamins are no longer recommended as the AREDS2 formula is at least as good, and the beta carotene in AREDS1 increases the risk of lung cancer in current smokers and perhaps also in past smokers.

Family members of people with macular degeneration often ask whether they should take AREDS2 vitamins or lutein/zeaxanthin. While these are safe to take during a period of at least five years (the duration of the AREDS2 study), it is not known whether it would be safe to take them for a number of decades. Therefore, it is recommended that family members eat foods containing high levels of lutein and zeaxanthin rather than take the supplements. These foods also contain hundreds of other phytochemicals that are likely to be helpful.

Video: Nutritional Supplements

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* Oxidative stress is a disturbance in the balance between the production of very reactive oxygen-containing molecules that can adversely interact with other molecules inside our cells, and our body’s ability to neutralize these molecules. It can be caused by bright light, a poor diet with not enough antioxidants, and too much iron in the retina. The resulting inflammation can contribute to a number of age-related diseases, including age-related macular degeneration. Antioxidants are molecules present in cells that can prevent these harmful reactions.

This content was first posted on: November 30, 2016

The information provided here is a public service of the BrightFocus Foundation and should not in any way substitute for personalized advice of a qualified healthcare professional; it is not intended to constitute medical advice. Please consult your physician for personalized medical advice. BrightFocus Foundation does not endorse any medical product, therapy, or resources mentioned or listed in this article. All medications and supplements should only be taken under medical supervision. Also, although we make every effort to keep the medical information on our website updated, we cannot guarantee that the posted information reflects the most up-to-date research.

These articles do not imply an endorsement of BrightFocus by the author or their institution, nor do they imply an endorsement of the institution or author by BrightFocus.

Some of the content may be adapted from other sources, which will be clearly identified within the article.

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