Defining Immunometabolic Contributions to Cognitive Impairment in Alzheimer's Disease

Certain molecules within different brain cells can govern metabolic processes that modulate the progression of Alzheimer’s disease and dementia. In this study, I have identified a molecule, referred to as p38MAPK, in a supportive brain cell type, known as astrocytes, that may regulate the neurobiological network involved in cognitive decline in Alzheimer’s disease. Therefore, I am proposing to use cutting-edge neuroscience techniques to eliminate production of p38MAPK in such astrocytes brain cells in attempt to slow disease and dementia progression in a mouse model of Alzheimer’s disease.