What We Do
BrightFocus Foundation funds exceptional scientific research worldwide to defeat Alzheimer’s disease, macular degeneration, and glaucoma and provides expert information to empower individuals and families.
Our Work
Fund Innovative Science
Our Robust Research Program
We provide initial funding for highly innovative, experimental ideas with the most significant promise to change a disease’s trajectory. Most of our grants support early-stage research, ensuring fresh perspectives and novel discoveries that fuel the field, delivering an increased return on research investment over time. BrightFocus grants undergo rigorous evaluation by the world’s top scientists and clinicians who serve on our scientific review committees.
Invest in Scientists
Paving the Future of the Field
BrightFocus educates, trains, and supports the next generation of brain and vision scientists. Taught by experts in the field, our signature Fast Track workshops and global travel fellowships have accelerated the careers and transformative ideas of thousands of early-career scientists worldwide.
Inform the Public
Sharing Public Resources and Educating Communities
BrightFocus empowers individuals and families with trusted information on research findings, healthy living, risk reduction, treatments, and living with diseases of mind and sight. We offer expert-vetted resources, community events, virtual programming, partnerships, and entertainment connecting the public to researchers, doctors, and expert information in multilingual formats.
Over 50 Years of Bold Research
Since our founding more than 50 years ago, we’ve funded the boldest research and “what-if” ideas to get us closer to cures, resulting in the novel treatments and diagnostic tools in use today. We also raise awareness and empower people with these diseases and their loved ones by sharing expert resources and information.
Our Commitment to Health Equity
Every population is impacted by Alzheimer’s, macular degeneration, and glaucoma, but they are not impacted equally. Health equity starts in the lab, and disparities are a public health problem that must be solved to prevent, treat, and cure mind and sight diseases. Central to the vision and mission of BrightFocus Foundation is a drive to fund the most promising scientific research so that we can all live a longer and more rewarding life.
BrightFocus is committed to:
- Funding the most promising and innovative research that approaches the diseases from diverse angles to have the best chance of defeating them for good.
- Growing community to reflect better and support every person impacted by mind and sight diseases.
- Supporting and educating scientists from all backgrounds to foster creativity and innovation in addressing complex scientific challenges. We strongly encourage applications from individuals who are from groups underrepresented in the field to apply for our grants. Nearly 45% of our funded researchers across 25 countries are women and from a non-white racial background.
- Reflecting the broad community we serve by hiring with a mindset of inclusivity. We believe diverse perspectives and representation amongst our staff and leadership are essential to better understanding and serving everyone.
- Increasing awareness across every community about mind and sight diseases, with an emphasis on under-resourced communities where there is a significant distrust in healthcare professionals and a lack of understanding about the diseases and the importance of taking them more seriously.
- Growing our strategic diversity, equity, and inclusion partnerships to better educate and engage with underserved communities in a meaningful way that provides value to these communities. We believe that change starts from within, and that success occurs when community ambassadors build relationships and trust as agents of change over time.
- Listening to and making changes in our initiatives to reflect better the voices of the people we serve.
- Ensuring our informational programs and materials meet the highest ADA standards for accessibility and low vision possible.
- Increasing our free multilingual resources.
Virtual Programs
Information Program Highlights
Our free information programs provide insight and support for affected individuals and their loved ones.
Zoom In on Dementia & Alzheimer’s
This live, interactive program featuring renowned research scientists and clinicians shares the latest research news and information, and participants can ask questions live or watch on demand. Topics range from newly approved treatments to genetics, risk reduction, and more.
Macular Chats and Glaucoma Chats
Our monthly, live audio discussions with vision experts empower people living with macular degeneration and glaucoma with the latest research and tips for living with low vision.
Age-Related Macular Degeneration Community Circle
This monthly, virtual program is designed to provide a place where people with macular degeneration can join together to share tips, ask questions, and build community.
Educating Through Film
BrightFocus has a long history of storytelling through film. We collaborate with filmmakers to share important stories and provide education about diseases of mind and sight.
Annual Report and Research Grant Portfolios
Every year, BrightFocus produces an annual report and research grant portfolios to highlight our currently funded research.
Donate Now to Fund Critical Research
Your gift today can help drive innovation in Alzheimer's, macular degeneration, and glaucoma research. By donating, you’ll support life-changing research and provide valuable resources for those affected by these devastating diseases. Give now to fuel hope and bring us closer to finding cures.
Powering Innovative Research
Article
Potential New Glaucoma Treatment Saves Retinal Cells
An innovative new approach to stopping excess glutamate signaling in the eye may help protect vision in people with glaucoma. BrightFocus National Glaucoma Research-funded scientist Marco Feligioni, PhD, is exploring a potential new treatment that could one day help preserve vision alongside existing glaucoma therapies.
Article
A New Macular Degeneration Suspect: The Eye's Light-Sensing Cells
After discovering that photoreceptors actively drive the debris formation seen in age-related macular degeneration, BrightFocus Macular Degeneration Research grantee Claudio Punzo, PhD, helped develop a single-injection gene-silencing therapy designed to reverse this process, opening a new avenue for treatment.
Article
FDA Clears Two Alzheimer's Blood Tests to Support More Accurate, Earlier Diagnoses
Two blood tests—PrecivityAD2 (C2N Diagnostics) and Elecsys pTau217 (Roche and Lilly)—have been cleared for use in clinical laboratory settings. Learn more about how the tests work and what FDA clearance means for people with cognitive impairment.
Press Release
'The Wire' Star Andre Royo Shares Personal Alzheimer's Story in New BrightFocus Foundation Awareness Campaign
A new campaign launched during World Alzheimer’s Month features renowned actor, producer, and writer Andre Royo, who lost his mother, Andrea Royo, to Alzheimer’s disease in 2024.
Article
Building a Better Model of Alzheimer’s By Studying Brain Tissue in a Dish
Dr. Dominik Paquet's lab is growing human brain tissue in the lab to uncover what mouse models can’t show.
Article
BrightFocus Journal Rises to Top 5 Neuroscience Journals Worldwide
With a 2025 impact factor of 19.6 and a No. 5 ranking among 330 neuroscience journals worldwide, Molecular Neurodegeneration continues to expand its influence on research into Alzheimer’s disease, macular degeneration, glaucoma, and related neurodegenerative disorders.