Treatments for Macular Degeneration
All macular degeneration starts as the dry form, where the macula increasingly thins through early, intermediate, and advanced stages. Dry age-related macular degeneration (AMD) can progress to the wet, more advanced, form, in which tiny, fragile blood vessels in the eye can leak and trigger inflammation. These two types of AMD have different treatment plans. Continue reading for more details.
Treating Macular Degeneration
If you’ve been diagnosed with AMD, it’s important to see your eye doctor regularly to track how quickly your disease progresses. Your doctor can tell you how to control risk factors for the disease and show you how to use the Amsler grid, a simple visual test so that you can detect subtle changes in your vision.
At the first sign of any visual changes, no matter how small they seem, you should make an appointment with your eye care provider.
Dry AMD Treatments
People with intermediate-stage dry AMD may benefit from taking a special mix of supplements to decrease their risk of losing central vision. In clinical trials, an over-the-counter combination of vitamins and minerals called the AREDS2 formula showed benefit in preventing the progression of intermediate dry AMD to late dry AMD. AREDS2 also may slow the development of wet AMD, the less common form of the disease.
AREDS2 Vitamin Supplement Formula
It’s important to find the right vitamins since many are marketed for eye health, but only a few have formulas that have proven effective. The recommended formula is:
- 500 mg of vitamin C
- 400 IUs of vitamin E
- 10 mg of lutein
- 2 mg of zeaxanthin
- 80 mg of zinc
- 2 mg of copper
You should always speak with your doctor before adding medications to your regimen.
FDA Approved Treatments
Two U.S. Food and Drug Administration-approved treatments for dry AMD are intended for people in a late stage of the disease who have been diagnosed with geographic atrophy. The first, Syfovre, was approved in February 2023, followed by Izervay in September 2023. Both are injections shown to reduce the rate of geographic atrophy lesion growth.
In 2024, the Valeda® Light Delivery System was approved for use in dry AMD. Valeda uses multiple wavelengths of light (red and near-infrared) to stimulate cellular processes within the retina, including mitochondrial activity, which can help reduce inflammation and promote healthy cell function.
Wet AMD Treatments
Wet AMD can be treated with injections of angiogenesis inhibitors into the eye, with photodynamic therapy, or with laser surgery. None of these treatments will cure wet macular degeneration, but each may slow the rate of vision decline or stop further vision loss.
Anti-VEGF and Other Injected Treatments
Anti-VEGF shots block vascular endothelial growth factor, a key molecule in the production of new blood vessels in a process called angiogenesis, and are injected into the back of the eye, which has been numbed beforehand.
Photodynamic Therapy
Photodynamic therapy (PDT) is most effective in a subtype of wet macular degeneration called predominantly classic subfoveal AMD, in which blood vessel growth and leakage in the fovea are well defined. PDT is rarely used now that there are drugs that specifically block the vessel-promoting VEGF protein.
Laser Surgery
Laser photocoagulation surgery was the first treatment used for wet macular degeneration, but it is only an option for a small number of patients.
Side Effects
For a complete list of side effects associated these treatments, please refer to our comprehensive list of Wet and Dry AMD treatments.
Frequently Asked Questions
Search for a Macular Degeneration Clinical Trial
Clinical trials are crucial to advancing the most effective medical approaches. Today’s studies will lead to new standards of care in the future.
Resources
Recent Resources & Information
Macular Chats
Geographic Atrophy: Making An Informed Treatment Choice
Learn about how to navigate treatment options, engage in shared decision-making with your healthcare team, and maximize your eye health.
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Wet AMD Treatments: Updates, Challenges, and Future Innovations
Join us for an in-depth discussion on the latest developments in wet age-related macular degeneration treatment.
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Podcast
New Option for Anti-VEGF Treatment for Wet AMD
Macular Chat guest speaker W. Lloyd Clark, MD, who will discuss a new anti-VEGF treatment option that is available for wet AMD.
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Treatment Options for Geographic Atrophy
Discover the latest on Geographic Atrophy treatment with Dr. Veeral S. Sheth. Explore advances in dry age-related macular degeneration therapies.
Downloadable Resource
Treatments for Macular Degeneration
Find information on treatment options for dry and wet age-related macular degeneration.