Controlling Eye Pressure in New Ways

A woman getting an eye exam


Elevated eye pressure, or intraocular pressure (IOP), is present in most forms of glaucoma. This can happen when the fluid that constantly bathes the front of the eye, called aqueous humor, gets clogged and backed up.  

Normally it aqueous humor fluid drains through a spongy tissue known as the trabecular meshwork which is the eye’s main drainage channel. The trabecular meshwork offers a certain resistance to the outflow of aqueous humor that is needed to maintain a steady-state eye pressure.  

In addition, eye pressure can be affected by fluid volume, and by other factors such as trabecular meshwork stiffness, which is reported to be 20 times higher in individuals with glaucoma than in normal eyes.  

BrightFocus funded grantees are unraveling novel mechanisms that regulate eye pressure and are looking for new ways to decrease stiffness and control eye pressure. 




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