Unlike most cells in the body, which repair themselves, the optic nerve cells that provide us with vision do not regrow once damaged.
Ultimately, glaucoma threatens sight by damaging the optic nerve, at the back of the eye which carries light signals from the eye to the brain.
BrightFocus supports both research that is looking for ways to protect optic nerve cells threatened as glaucoma progresses, as well as research to find ways to regenerate and repair cell after vision loss.
The biggest focus of our efforts is to replace and reconnect retinal ganglion cells (RGCs), nerve cells that make up the optic nerve and carry visual signals over long tails (axons) extending from the eye to the brain. This is a sophisticated undertaking, given how RGCs are wired into the brain.
Explore More of Our 360° Research Approach
- New Knowledge About What Causes Glaucoma
- New Ways to Predict Progression and Treat Glaucoma
- Controlling Eye Pressure in New Ways
- Imaging and Exploring the Eye-Brain Connection
New Knowledge About What Causes Glaucoma
Glaucoma is a group of eye diseases united under one name. Ultimately, glaucoma threatens sight by damaging the optic nerve, at the back of the eye which carries light signals from the eye to the brain. However, our knowledge of how and when glaucoma damages nerve cells remains imprecise.
New Ways to Predict Progression and Treat Glaucoma
Currently approved treatments for glaucoma primarily focus on eye pressure. Numerous therapies exist to lower eye pressure effectively; however, the bulk of them (eyedrops and surgeries) require skill and consistency to achieve results.
Easier methods are needed, as well as new therapies to address other underlying causes of glaucoma besides intraocular pressure (IOP).
Controlling Eye Pressure in New Ways
Elevated eye pressure, or intraocular pressure (IOP), is present in most forms of glaucoma. This can happen when the fluid that constantly bathes the front of the eye, called aqueous humor, gets clogged and backed up.
Imaging and Exploring the Eye-Brain Connection
Eye changes associated with glaucoma contribute to tiny blind spots, known as “visual field defects,” which, if they worsen, might advance to vision loss and blindness. The chance of that, and the speed at which it happens, vary greatly from person to person.
Early diagnosis is key, and much progress has been made in imaging the eye to detect the tiniest changes that may precede glaucoma.