Alzheimer’s Disease Research
Alzheimer’s Disease Research, a BrightFocus Foundation program, drives innovative research worldwide to defeat Alzheimer’s disease and related dementias. By providing initial funding for highly innovative, experimental research and creative ideas, we spark revolutionary approaches and life-saving breakthroughs for this devastating disease impacting more than 7.2 million Americans aged 65 and older.
Our Impact: Making a Difference
Alzheimer’s Disease Research currently supports a global portfolio of 111 innovative scientific grants working toward a cure. Our grants are vetted through a rigorous evaluation process by the world’s top scientists and clinicians who serve on our Scientific Review Committee.
111
Active research grants we’re supporting worldwide
366
Scientists currently supported through our grants
More than $192 million
Invested in Alzheimer’s research grants since inception
Recent News
News & Breakthroughs
4 Takeaways from Alzheimer’s Fast Track 2025
This innovative meeting hosted by BrightFocus Foundation bridges cutting-edge science, mentorship, and community building for early-career researchers.
Understanding Alzheimer’s & Exploring New Frontiers in Treatment
Watch a conversation inspired by the documentary film Taking Care and the latest research in Alzheimer’s therapies.
Alzheimer’s Science News: Fall 2025
In this issue: A Blood Test That Could Personalize Alzheimer’s Care • Researcher Spotlight: Hannah Ennerfelt, PhD • The Healing Power of Pets • And more!
Shaping the Future of National Alzheimer’s Research Priorities
BrightFocus Foundation’s VP of Scientific Affairs helped set national research priorities at the federal Alzheimer’s Disease-Related Dementias Summit, influencing how billions in NIH funding will advance dementia research and care.
New Clues in the Fight Against Alzheimer’s: Q&A with Dr. Keith Hengen
During World Alzheimer’s Month, Alzheimer’s Disease Research grantee Dr. Keith Hengen joined BrightFocus’ Dr. Sharyn Rossi on Instagram Live to talk brain health—how the brain functions, why quality sleep matters, and tips to keep your brain healthy.
Targeting Genetic Triggers of Inflammation in Alzheimer’s Disease
A BrightFocus Alzheimer’s Disease Research-funded scientist is investigating how “jumping genes” may fuel brain inflammation in Alzheimer’s—and whether blocking them could prevent or slow dementia.
FDA Approves At-Home Injectable Leqembi for Alzheimer’s
New formulation of Leqembi allows weekly at-home injections, reducing the need for hospital visits.
Alzheimer’s Science News: Summer 2025
In this issue: Hope for Adults with Down Syndrome, Preview of New Research, Hygiene Tips for Those with Alzheimer’s, and more!
Home-Based Alzheimer’s Treatment Brings Care Closer to Families
A team of BrightFocus Alzheimer’s Disease Research-funded scientists is exploring how home-based brain stimulation could improve memory, mood, and daily life for people living with Alzheimer’s disease.
Why It Matters
Why Alzheimer’s Disease Research Matters
Our greatest opportunity to find a cure for Alzheimer’s disease lies in research.
Thanks to generous donor support, Alzheimer’s Disease Research has invested more than $189 million in groundbreaking studies aimed at furthering our understanding of the disease.
With our grants, scientists across the globe are exploring and testing thousands of hypotheses regarding the disease’s onset and progression, leading to the creation of improved earlier detection strategies and new treatments.
Our Approach to Research
Alzheimer’s Disease Research takes a 360-degree approach to funding innovative scientific research worldwide to defeat Alzheimer’s disease. We explore the full range of scientific paths–from genetics to biomarkers–to improve treatments and ultimately find a cure.
Resources
We’re here for you.
The Next Generation of Alzheimer’s Treatments
Join behavioral neurologist Dr. Marwan Sabbagh for an in-depth discussion about emerging Alzheimer’s therapeutics now in late-stage clinical development.
Why Some Brains Stay Sharp With Age
Learn how cognitive reserve can make some people more resistant to memory decline.
Understanding Alzheimer’s Disease
Alzheimer’s disease affects people’s memories, but it involves far more than simple forgetfulness. Learn more about this devastating disease.
FDA-Approved Alzheimer’s Therapies Infographic
Although there is no cure for Alzheimer’s disease, certain treatments can help control or delay its symptoms, particularly in the early stages of the disease. Talk to your physician to see if these medications are right for you.
The Gut Microbiome and Alzheimer’s Disease: Understanding the Connection
Join Dr. Beau Ances of Washington University in St. Louis to learn about the emerging science linking gut health and brain health.
“Help the One You Can”
Meet Mel and Irene Sahyun, donors to BrightFocus’ Alzheimer’s Disease Research program.
U.S. POINTER Study Update: Lifestyle Program Significantly Improves Cognition in Older Adults
Can everyday lifestyle choices really protect your memory? Dr. Laura Baker, professor at Wake Forest University School of Medicine, will share results from the groundbreaking U.S. POINTER trial—the largest study of its kind to test how lifestyle changes impact brain health.
Can GLP-1 Weight Loss Drugs Treat Alzheimer’s?
Recent research suggests that GLP 1 analogs—a class of drugs used to control blood sugar—may also protect brain health, improve memory, and slow neurodegeneration.
Every Donation is a Step Forward in the Fight Against Alzheimer’s
Your donation powers cutting-edge research and helps scientists explore new treatments. Help bring us closer to a cure and provide valuable information to the public.
Grants & Scientists
Apply for a Research Grant
Alzheimer’s Disease Research provides research funds for U.S. domestic and international research proposals pursuing innovative treatments, prevention strategies, and a cure for Alzheimer’s disease.