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Prescription Medications That Can Affect Age-Related Macular Degeneration

Joshua Dunaief, MD, PhD

Scheie Eye Institute, University of Pennsylvania

  • Expert Advice
Published on:
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Patients often ask if their medications affect the risk of vision loss from age-related macular degeneration (AMD). One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect.

An Exception to the Rule

Fortunately, very few prescription drugs have any known detrimental effects for people with AMD. Warfarin (Coumadin®), which is an anticoagulant blood thinner, is one exception. Doctors often put patients with certain potentially life-threatening cardiovascular conditions on this blood thinner. Studies have shown that patients with wet AMD, which causes bleeding from abnormal blood vessels in the macula, may have larger amounts of blood entering a space under the retina (subretinal hemorrhages) if they take warfarin. This can lead to more severe vision loss. Warfarin does not increase the risk of vision loss in patients with dry AMD.

Some patients need to take warfarin to protect their lives, even if they have wet AMD. Others with wet AMD can be switched to other blood thinners such as aspirin, which has not been shown to increase the size of the retinal hemorrhages. Your ophthalmologist along with your other physicians can develop a treatment plan that is best for you. Please never make medication changes without first talking with your doctors.

Another issue in patients taking warfarin is that green leafy vegetables can decrease the drug’s anti-clotting effects by providing vitamin K. Some patients on warfarin will be told not to eat leafy greens because this makes it harder to regulate the warfarin dose. Yet, eating these same leafy greens has been shown to decrease the risk of vision loss from AMD. The best solution for many patients is to eat a consistent amount of leafy greens each day and have a blood test for warfarin regularly.  The test is called an INR (international normalized ratio) and it determines how well warfarin is working by evaluating blood clotting time.

A Beneficial Effect?

Another drug class that may affect AMD is statins, which are drugs that reduce the level of fats, including cholesterol, in the blood.  Currently, there is mixed evidence on the effects of statins.  However,  one small study at Harvard showed that a relatively high dose (80mg) of Lipitor® (atorvastatin) can decrease the size of drusen (abnormal lipid/protein deposits under the retina in patients with early dry AMD), and sometimes improve vision in patients with very large drusen right in the center of the macula. A larger (phase III) clinical trial is planned to determine which patients are likely to benefit.

A Warning about Vitamins

For patients with drusen, vitamins are protective. The Age-Related Eye Disease Study showed a 25 percent reduction in risk of AMD progression to advanced disease in patients taking the “AREDS2” formula. It is important not to overdose on vitamins, so patients on AREDS2 supplements should not take additional large amounts of vitamin E, zinc or copper. Since many of the common multivitamins for older individuals have relatively small levels of these vitamins and minerals, talk to your doctor about whether you can take a multivitamin along with your AREDS2 supplements.

Prevention Advice

The best prescription for AMD prevention is lifestyle changes. Substantial evidence indicates that a diet rich in green leafy vegetables (every day), fruits (every day), and fatty fish (like salmon, twice a week) is protective. So is avoiding obesity and exercising. Smoking is a significant risk factor.
 

About the author

dr._joshua_dunaief_new

Joshua Dunaief, MD, PhD

Scheie Eye Institute, University of Pennsylvania

Joshua Dunaief, MD, received his BA magna cum laude in Biology from Harvard (1987), MD/PhD from Columbia College of Physicians and Surgeons (1996), completed ophthalmology residency at the Wilmer Eye Institute, Johns Hopkins in 2000, and medical retina fellowship at Scheie Eye Institute, University of Pennsylvania in 2004.

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