Regulation of Tau Homeostasis by Molecular Chaperones

Alzheimer’s disease is a devastating condition that impacts patients, their families and their caregivers. There are no treatments for this disease, so a major goal of our group is to pursue new and unconventional ways of preventing it. In the current proposal, we are trying to understand how the body’s own proteins (termed molecular chaperones) protect us against Alzheimer’s disease. At the same time, we hope to learn why this system fails during disease, so we can use this knowledge to design drugs that activate the molecular chaperones.