Mitochondrial Prodrug to Treat Repeated Mild Traumatic Brain Injury

Principal Investigator
Patrick Sullivan, PhD
University of Kentucky Research Foundation
Lexington, KY, USA
About the Research Project
Program
Award Type
Bold Ideas initiatives
Award Amount
$500,000
Active Dates
September 08, 2021 - December 31, 2023
Grant ID
CA2021015
Goals
This study aims to test the safety and efficacy of a mitochondrial stabilizing drug, MP201.
Summary
Traumatic brain injuries, especially when repetitive, can lead to oxidative stress and mitochondrial dysfunction that can contribute to dementia. MP201 has been shown to be therapeutically effective in multiple animal models and clinical indications and will be used for a full Investigational New Drug-enabling toxicology package with the FDA.
Unique and Innovative
This proposal will be one of the first projects to examine mitochondrial function and treatment after mild traumatic brain injury. This project will extend an innovative fractionated mitochondrial magnetic separation technique for use in rat brain tissue. This project will stimulate research to move a promising drug MP201 into clinical trials.
Foreseeable Benefits
This study will produce scientific data in an understudied area of mitochondrial dysfunction following mild TBI as a direct benefit to the research field. The project will also generate potential of a drug candidate that could be used in clinical trials for TBI. An effective drug would greatly benefit those suffering from TBI and caregivers alike.
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