ER-Mitochondrial Interactions in Familial Alzheimer's Disease
About the Research Project
Program
Award Type
Pilot
Award Amount
$150,000
Active Dates
April 01, 2008 - March 31, 2010
Grant ID
A2008111
Goals
ER-Mitochondrial interactions in familial Alzheimer’s disease
Summary
We have discovered that presenilin-1, a protein that, when mutated, causes familial (i.e. inherited) Alzheimer disease, is located in a specialized compartment of the cell, called endoplasmic reticulum-mitochondria-associated membranes (ER-MAM). This novel finding suggests a new mechanism by which the disease arises. We propose a number of experiments aimed at understanding the role of ER-MAM in the pathogenesis of Alzheimer disease.
Related Grants
Alzheimer's Disease Research
The Role of DYRK1A in Altered Microglia Biology in a Cellular Model of Alzheimer’s Disease in Down Syndrome
Active Dates
January 01, 2025 - December 31, 2027
Principal Investigator
Frances Wiseman, PhD
Current Organization
University College London (UK)
The Role of DYRK1A in Altered Microglia Biology in a Cellular Model of Alzheimer’s Disease in Down Syndrome
Active Dates
January 01, 2025 - December 31, 2027
Principal Investigator
Frances Wiseman, PhD
Current Organization
University College London (UK)
Alzheimer's Disease Research
Mechanisms of Inhibitory Neuron Vulnerability to Alzheimer’s Disease
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Emiliano Zamponi, PhD
Current Organization
Columbia University
Mechanisms of Inhibitory Neuron Vulnerability to Alzheimer’s Disease
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Emiliano Zamponi, PhD
Current Organization
Columbia University
Alzheimer's Disease Research
Shining a Light on How Early Tau-Related Brain Changes Affect Memory Loss
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Martin Dahl, PhD
Current Organization
Max Planck Institute for Human Development (Germany)
Shining a Light on How Early Tau-Related Brain Changes Affect Memory Loss
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Martin Dahl, PhD
Current Organization
Max Planck Institute for Human Development (Germany)