ER-Mitochondrial Interactions in Familial Alzheimer's Disease
About the Research Project
Program
Award Type
Pilot
Award Amount
$150,000
Active Dates
April 01, 2008 - March 31, 2010
Grant ID
A2008111
Goals
ER-Mitochondrial interactions in familial Alzheimer’s disease
Summary
We have discovered that presenilin-1, a protein that, when mutated, causes familial (i.e. inherited) Alzheimer disease, is located in a specialized compartment of the cell, called endoplasmic reticulum-mitochondria-associated membranes (ER-MAM). This novel finding suggests a new mechanism by which the disease arises. We propose a number of experiments aimed at understanding the role of ER-MAM in the pathogenesis of Alzheimer disease.
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