Defining the Impact of Cytokine Signaling in Alzheimer’s Disease

About the Research Project
Program
Award Type
Standard
Award Amount
$200,000
Active Dates
July 01, 2024 - June 30, 2026
Grant ID
A2024030F
Mentor(s)
Anna Molofsky, MD, PhD, University of California, San Francisco
Goals
This project aims to determine the mechanistic impact of a key immune pathway in AD pathology, potentially leading to novel approaches for AD immunotherapies.
Summary
Immune signals regulate brain homeostasis and are also a major driver of Alzheimer’s disease pathology. This proposed study aims to investigate how astrocyte-microglia crosstalk via IL-33 cytokine impacts Alzheimer’s disease pathology and behavior. This work will determine the mechanistic impact of a key immune pathway in AD pathology and suggest the novel hypothesis that ECM disruption is linked to AD pathology.
Unique and Innovative
I will use strategies for targeted manipulation of cytokine signaling. Viral-mediated cytokine delivery by glial cells will be utilized as a gain-of-function strategy. The study will provide new insight into the mechanisms of glial involvement in amyloid pathology.
Foreseeable Benefits
This work will determine the mechanistic impact of a key immune pathway in Alzheimer’s disease pathology. The study will provide new insights into the mechanisms of tissue damage and how immune signals impact amyloid pathology.
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