Chlamydia Pneumonia Infection and Incidence of Age-Related Macular Degeneration

Principal Investigator
Luba Robman, MBBS, PhD
Centre for Eye Research Australia (Australia)
Melbourne, Australia
About the Research Project
Program
Award Type
Standard
Award Amount
$50,000
Active Dates
April 01, 2005 - March 31, 2006
Grant ID
M2005012
Summary
Recent studies have indicated an inflammatory component in the development of age-related macular degeneration (AMD). It is biologically plausible that such an inflammation is either caused by or aggravated in the presence of chronic infection. Two cross-sectional studies have demonstrated the prevalence of antibodies to Chlamydia pneumonia elementary bodies to be significantly higher in subjects with AMD compared to age-matched controls. Dr. Robman believes that Chlamydia pneumonia infection may play a causal role in the development of AMD and, therefore, aims to test an association between exposure to the Chlamydia pneumonia infection and the incidence of early AMD. If the causative link between Chlamydia pneumonia infection and the development of AMD is confirmed, long-term clinical trials of antibiotic therapy will be necessary to confirm or refute a pathogenic role for these organisms.
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