Learn about the roles that one’s sex (determined by genes and chromosomes), and gender (social role and preferred orientation) play in the risk for developing Alzheimer’s disease (AD) in men. We examine how they may impact the course of the disease.
Hector’s story and his examination results suggest that he is in the early stage of a mild cognitive decline, possibly the one in which memory is most affected. For many people, this condition is an early step on the path to AD. As a man, Hector’s sex (determined by his genes, and specifically by his possession of a Y chromosome) and his gender (his social role and preferred orientation) play important roles in his risk for developing AD and the course which his disease will take. Clinicians and researchers have been learning more about this issue lately, and here are some of the things they’ve found:
- As a man, Hector’s risk of developing AD is less than a woman’s. The average 65-year-old man, for example, has a 6.3 percent risk of developing AD during the remainder of his life while the risk for a 65-year-old woman is 12 percent, nearly twice as great. There is still uncertainty about whether this is because women live longer. Sex-related effects help to lower men’s risk. One way that sex affects risk is through the male hormone, testosterone. Some testosterone is transformed into estrogen, and estrogen seems to protect healthy brain cells. Men in later life do not experience the massive decrease in estrogen levels that women do after menopause, and that may reduce men’s risk for AD. Sex also affects the danger of various risk factors. One of these, the E4 version of the apolipoprotein gene, referred to as ApoE4, is a less potent risk factor for men than for women.
- Hector’s gender, his culturally determined role behavior, also plays a key role in his risk of developing AD. In some ways, gender has worked on Hector’s behalf. As a man in his 70s, he was raised during an era when men typically reached a higher level of education. Men of his era also tended to be more physically active than women. Higher educational level and physical activity have protective benefits against AD.
On the other hand, his generation of men smoked and drank alcohol more heavily than women, and these are risk factors for developing AD. The demographics of these risk factors are changing as women’s educational achievements match men’s. Unfortunately, women now smoke and drink more, too.
- Hector is married, which has a protective benefit for men and also means that his wife and daughter are likely to become his caregivers if his mild neurocognitive disorder progresses to AD. Hector’s family will want to know that men with AD experience a slower cognitive decline during the course of AD. On the other hand, men do not survive for as long a period as women after diagnosis, perhaps because they are typically diagnosed later in the course of the disease.
- As a man with AD, Hector may become challenging to care for at home. Men with AD are more likely than women to develop combative or aggressive behavior. In one study, hospitalized men with dementia and behavioral symptoms were less likely to be discharged back home than women with dementia and behavioral symptoms. The women’s symptoms were less likely to include aggression.
Some of the ways in which sex and gender affect risk and disease course are modifiable through healthy lifestyle changes such as smoking cessation and physical activity. And Hector’s family will be better prepared to support him through the course of his illness by understanding how his sex and gender may alter the path of his journey, and theirs, through his illness.
- Alzheimer’s Disease Toolkit (Helpful Information to Understand and Manage Alzheimer's Disease)
- Expert Information on Alzheimer's Disease (Articles)
- Alzheimer's in Women (Article)
- Decreasing Your Risk of Alzheimer’s (Article)
- What Is Your Risk?—Heredity and Late-Onset Alzheimer's Disease (Article)
- Is Alzheimer’s a Genetic Disease (Article)
- Beyond Brain Games: What’s a Brain-Healthy Lifestyle? (Article)
- The Challenging Behaviors of Alzheimer’s Disease - Part One (Article)
- Is it Alzheimer's (Article)
- Understanding Alzheimer's Disease: It's Not Just Forgetfulness (Publication)
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This content was last updated on: September 4, 2018
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