Expert

Blood Pressure and Glaucoma

University of California, San Francisco, UCSF Medical Center
Monday, March 27, 2017
Man taking his blood pressure and recording the results.

The relationship between blood pressure and glaucoma risk is complicated. Learn why both high and low blood pressure may increase the risk for this eye disease.

As with many aspects of our health, moderation is key with regard to blood pressure levels and risk of glaucoma. Very high blood pressure is not good for glaucoma because it raises eye pressure; however, moderate to very low blood pressure is also a problem because it is important for the optic nerve to receive enough blood flow.

High Blood Pressure

There have been conflicting studies as to the nature of the relationship between high blood pressure and glaucoma. What doctors do know is that increasing blood pressure does result in increasing eye pressure, possibly because high blood pressure increases the amount of fluid the eye produces and/or affects the drainage of that fluid out of the eye.

However, even though there is a positive relationship between blood pressure and eye pressure (for example, increasing blood pressure results in increasing eye pressure), the effects are not very large. It is estimated that blood pressure needs to increase by 10 mmHg (millimeters of mercury) in order to raise the eye pressure 0.26 mmHg.

In addition to increasing eye pressure and the possible risk of glaucoma, it is important to keep in mind that high blood pressure can also cause damage to the retina and result in hypertensive retinopathy, which is damage to the retina and retinal circulation.

Finally, of course, high blood pressure increases the risk of heart disease and stroke, so it is crucial to treat.

Low Blood Pressure

On the other hand, having low blood pressure can be a risk factor for developing glaucoma, as several large studies have shown. Specifically, ocular perfusion pressure, which is essentially the difference between blood pressure and eye pressure, is a risk factor for glaucoma diagnosis. This situation can occur in patients who naturally have low blood pressure, but also for patients with high blood pressure who are overtreated with medications.

Another time when low blood pressure may become an issue is when blood pressure naturally dips at night. Both blood pressure and eye pressure vary over the course of the day, and in situations where blood pressure drops and eye pressure increases overnight, damage to the optic nerve could be occurring.

Talk with Your Doctors

Based on these complexities, it is important to have a conversation with both your internist or primary care physician and your treating ophthalmologist if you have concerns about your blood pressure and glaucoma.

It is important to tell your ophthalmologist your medical conditions, including whether you have high blood pressure and if you are taking blood pressure medications.

This is particularly important with regards to your glaucoma treatment because one of the commonly used glaucoma medications is a topical beta-blocker eye drop. Systemic (oral) beta-blockers are used to treat high blood pressure. In addition to lowering blood pressure, a beta-blocker side effect is decreased heart rate. Therefore, simultaneous use of both a systemic beta-blocker and a beta-blocker in eye drop form could potentially have unwanted side effects.

Another example is if you are a dialysis patient with chronic kidney disease, which can result from diabetes or high blood pressure, among other causes. During dialysis, blood pressure can fluctuate and dip, leading to low ocular perfusion pressure. If you are a dialysis patient with glaucoma, it is important to discuss your conditions with your kidney specialist and your ophthalmologist. There are, for example, ways that the doctor can adjust the dialysis protocol so that there is less risk to your optic nerve.

Overall, it is best to avoid extremes in our blood pressure, so that it is not too low and not too high. There is ongoing research to try to identify the exact relationship between blood pressure and glaucoma so that doctors can better guide their glaucoma patients.

Resources

The information provided here is a public service of the BrightFocus Foundation and should not in any way substitute for personalized advice of a qualified healthcare professional; it is not intended to constitute medical advice. Please consult your physician for personalized medical advice. BrightFocus Foundation does not endorse any medical product, therapy, or resources mentioned or listed in this article. All medications and supplements should only be taken under medical supervision. Also, although we make every effort to keep the medical information on our website updated, we cannot guarantee that the posted information reflects the most up-to-date research.

These articles do not imply an endorsement of BrightFocus by the author or their institution, nor do they imply an endorsement of the institution or author by BrightFocus.

Some of the content may be adapted from other sources, which will be clearly identified within the article.

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