Selene Lomoio, PhD
Selene Lomoio is currently a postdoctoral fellow in the Neuroscience Department at Tufts University School of Medicine. She began her research in the Alzheimer’s disease (AD) field in 2005, as an undergraduate student at the Camillo Golgi Department for Cell Biology and Neuroscience in Pavia, Italy. She received her PhD in Cell Biology and Neuroscience in 2012, from University of Pavia (Italy) and Neuropathological Institute (IDIBELL), University of Barcelona (Spain). Under the supervision of Dr. E. Scherini and Dr. I. Ferrer, she conducted morphological, molecular and functional studies on sporadic and familial AD mouse models in order to elucidate the role of the cerebellum in this pathology. Three years ago she transitioned to Dr. Giuseppina Tesco’s team to focus her work on the role of the clathrin adaptor GGA3 in BACE1 trafficking, the key rate-limiting enzyme that initiates the formation of Aβ peptide in AD. Her recent studies indicate that GGA3, depleted in AD patient brains, plays a pivotal role in BACE1 axonal sorting regulation. The mechanism of this regulation is not known yet. Therefore, the identification of GGA3-mediated BACE1 axonal transport machinery would be extremely important to determine the extent to which GGA3 mediated regulation of BACE1 may represent a potential treatment for Alzheimer’s disease.