Understanding initiation of blood vessel growth in the eye

Xiaoxi Qiao, PhD
Indiana University School of Medicine (Indianapolis, IN)
Year Awarded:
2007
Grant Duration:
April 1, 2007 to March 31, 2009
Disease:
Macular Degeneration
Award Amount:
$100,000
Grant Reference ID:
M2007042
Award Type:
Standard
Award Region:
US Midwestern

TFPI-VLDLR Pathway in Retinal Angiogenesis

Summary

Very Low Density Lipid Receptor deficient mice show blood vessel growth in the eye similar to that seen in AMD. This project examines genes in this molecular pathway to determine how this pathway modulates new blood vessel growth.

Details


Age-related macular degeneration (AMD) is the most common cause of severe and irreversible vision loss in older adults in the US. The key lesion in the eye is abnormal vessel growth in the retina. Although several risk factors have been named, what molecule triggers the abnormal vessel growth is still not clear. A recent study reported that similar abnormal vessel growth was found in the eyes of a mutant mouse which lacks very low density lipid receptor (vldlr). The current proposal is to examine the role of vldlr as well as its known up- and down-stream molecules on the abnormal vessel growth in the eye. We will use this mutant mouse model and look for potential differences between the normal control and the mutant mice. We will also use retinal vascular cell culture to determine if vldlr and related molecules are the key pathway to stimulate abnormal vessel growth. Identify key molecules responsible for abnormal vessel growth will provide us new targets to develop better treatment strategy for AMD.

Publications

1 Hu W, Jiang A, Liang J, Meng H, Chang B, Gao H, and Qiao X, (2008) Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation, Invest Ophthalmol Vis Sci, 49:407-415.  

Jiang A, Hu W, Meng H, Gao H, and Qiao X, (2009) Loss of VLDL receptor activates retinal endothelial cells and promotes angiogenesis, Invest Ophthalmol Vis Sci, 50:844-850.  

Meng H, Hu W, Liang J, Jiang A, Wang W, Chang B, Gao H, and Qiao X, Early activation of multiple inflammatory cytokines and macrophage in vldlr deficient mice, in submission.
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