Signaling in RPE cell survival

Nicolas Bazan, MD, PhD
Louisiana State University Health S (New Orleans, LA)
Year Awarded:
2004
Grant Duration:
August 1, 2004 to July 31, 2007
Disease:
Macular Degeneration
Award Amount:
$300,000
Grant Reference ID:
M2004345
Award Type:
Standard
Award Region:
US Southern

Signaling in RPE cell survival

Details

Dr. Bazan will be examining human retinal pigment epithelial (RPE) cells in lab cultures while simulating conditions that occur in the eye with age-related macular degeneration. RPE cells form an important membrane separating the retina's light-sensitive rod and cone cells from another membrane, called Bruch's membrane. In the early form of the disease, called “dry” macular degeneration, the RPE cells slowly degenerate along with the cells of the retina. When macular degeneration becomes advanced, as in the “wet” form of the disease, bleeding from abnormal blood vessels can burst through Bruch's membrane and the RPE cell layer, damaging or destroying the fragile rods and cones. All vision loss due to this cellular damage is irreversible. The specific focus of Dr. Bazan's study will be to identify signaling chemicals that cue the RPE cells whether to survive or die, and he hopes to identify the agents that help RPE cells survive under disease conditions. The discovery of a protective agent for RPE cells could lead to a drug therapy that could be used early in the course of age-related macular degeneration, before too much damage has occurred.

Publications

Bazan, N.G. (2007) Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. Invest Ophthalmol Vis Sci. 48(11):4866-4881.  

Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D. and Bazan, N.G. (2007) Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci USA. 104(32):13152-7. Epub 2007 Aug 1.  

Bazan, N.G. (2006) Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends in Neuroscience. 29(5):263-271.  

Faghiri, Z. and Bazan, N.G. (2006) Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 47(1):397-404.  

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