The Role of Matrix Metallproteinases in ARMD

Shalesh Kaushal, MD, PhD
Regents of the University of Minnesota (Minneapolis, MN)
Year Awarded:
2001
Grant Duration:
April 1, 2001 to March 31, 2002
Disease:
Macular Degeneration
Award Amount:
$50,000
Grant Reference ID:
M2001002
Award Type:
Standard
Award Region:
US Midwestern

The Role of Matrix Metallproteinases in ARMD

Details

Matrix metalloproteinases (MMPs) are critical in the active regulation of the extracellular matrix. There are at least 10 different types of these digestive proteins. They are produced in an inactive form by RPE cells, and can be activated by various stimuli. At least two specific MMPs, MMP-2 and MMP-9, are found in the Bruch's membrane and they accumulate with age. This enzyme-based remodeling system suggests that it may be possible to enhance the transport characteristics of Bruch's membrane by turning on the tissue's own rejuvenation system. Dr. Kaushal seeks to understand how the active forms of MMP-2 and 9 can alter the structure and function of Bruch's membrane as the eyes age. He will also study methods for the activation of these MMPs to determine if the aging process can be offset by the eye's ability to repair itself.
Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.