Mechanism of Transpupillary Thermotherapy in CNV

Michael Tolentino, MD
Scheie Eye Institute (Philadelphia, PA)
Year Awarded:
2001
Grant Duration:
April 1, 2001 to March 31, 2002
Disease:
Macular Degeneration
Award Amount:
$50,000
Grant Reference ID:
M2001007
Award Type:
Standard
Award Region:
US Northeastern

Mechanism of Transpupillary Thermotherapy in CNV

Details

Hyperthermia, or heat, has been used to treat tumors for many years. One way that heat can destroy tumors is to damage the new blood vessels that feed the tumor. Because of this possibility, laser-induced hyperthermia or transpupillary thermotherapy (TTT) has been used to treat the new blood vessels occurring in the choroidal cell layer that lead to legal blindness in patients with age-related macular degeneration. Although human clinical trials have started, the dose of heat given has been based on cancer data. There is very little information on how heat affects the normal eye or an eye with new blood vessels. Dr. Tolentino is studying the effect of TTT on normal eye tissue and eye tissue that has neovacularization in order to establish a dosage level that can be used as a guideline for human therapy. His goal is also to determine the correlation between laser power and temperature and the factors that can alter their relationship, such as pigmentation, subretinal fluid and the wavelength of the laser. In addition, Dr. Tolentino hopes to gain a better understanding of programmed cell death and the production of heat shock proteins in order to have a better understanding of how TTT affects the eye.
Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.