Identifying Gene Pathways in Late-Stage AMD

Paul Baird, PhD
Centre for Eye Research Australia, The University of Melbourne (Melbourne, Australia)

Co-Principal Investigators

Adam Kowalczyk, PhD
University of Melbourne
Year Awarded:
2016
Grant Duration:
July 1, 2016 to June 30, 2018
Disease:
Macular Degeneration
Award Amount:
$80,000
Grant Reference ID:
M2016178
Award Type:
Standard
Award Region:
International
Paul Baird, PhD

Identifying Gene Pathways that Delineate the Two Late-Stage Types of Disease in AMD

Summary

There are two types of blinding age-related macular degeneration (AMD) but treatment is only currently available for one of these. We have developed a novel statistical tool and high throughput computational model that allows us to look at all genes in our genome and identify those genes that interact with each other to cause both of these types of AMD. Using the world’s largest collection of AMD samples, drawn from multiple cohorts of 40,000 people, we will identify the important genetic interactions in each type of AMD. Using this knowledge, we will be able to better understand the disease process and develop new therapies allowing both types of blinding AMD to be treated.

Details

This project will look at how different regions of our genetic background interact with other genetic regions and lead to AMD. This will also allow us to identify whether specific gene-gene interactions exist for each of the different types of late -stage AMD (either geographic atrophy, aka “dry AMD,” or choroidal neovascular disease, known as “wet AMD”). In the first aim, data from the international AMD Gene Consortium, of which I am a member, will be used. This is a large consortium consisting of over 40,000 patient samples with and without AMD, from over 20 different groups from around the world. Coupled with these patient resources, a new statistical tool that allows investigation of gene-gene interactions has been developed called genome wide interaction search (GWIS).  This will allow all genes in an individual AMD patient to be assessed and compared to an individual without AMD to identify particular gene-gene interactions specific to those individuals with AMD. This will be repeated across all subjects in each of the cohorts and then across all available cohorts. The power of the GWIS comes from the ability to be able to investigate large numbers of patients across multiple cohorts.

In the second aim, the GWIS will be used to identify specific gene-gene interactions that exist in either geographic atrophy or choroidal neovascular disease from patients from the international AMD Gene Consortium. This will allow identification of specific pathways that are important for each type of AMD.

The findings from this research will allow a better understanding of what causes AMD and in particular what causes either of the different late-stage disease subtypes of geographic atrophy or choroidal neovascular disease. In turn, it is envisaged that novel treatments will be developed based on these findings.

About the Researcher

I am a professor in the Department of Ophthalmology at the University of Melbourne. I also head the Ocular Genetics Unit at the Centre for Eye Research (CERA) as well as being Academic Coordinator and Research Coordinator (Education) for my department and CERA. I have been awarded many national and internationally competitive grants and I am a current recipient of a prestigious and highly competitive 5-year National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship. I have published over 160 journal articles, including in top ranked journals such as Nature Genetics and Lancet and have established an expansive network of collaborations both nationally and internationally. In particular I am actively involved in international consortia through my work in AMD and co-chair of working groups. I am frequently invited to participate in, and help organize, national and international conferences and present at national and international meetings. I am a member of various committees, including the Human Research Ethics Committee at the Royal Victorian Eye and Ear Hospital.

Personal Story

I am passionate about improving people’s lives through maintaining their quality of life for as long as possible. As such, maintenance of our sight is imperative for active participation in the connected age and for full enjoyment of life and work. I have worked in medical research for 30 years in areas as diverse as microbiology and children’s cancer but I find with eye research, and macular degeneration in particular, there are diseases where we are now beginning to make a real difference to a large number of people. The area of genetics research in AMD is at an exciting juncture as this work has the real potential to impact on the many millions of people around the world with AMD. I am particularly grateful to BrightFocus Foundation for their support for this project and to you, the donors, who have given your generous support, and I hope to reward your generosity with encouraging developments in this field.

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