A zebrafish model of AMD

Deborah Stenkamp, PhD
University of Idaho (Moscow, ID)
Year Awarded:
2004
Grant Duration:
April 1, 2004 to September 1, 2008
Disease:
Macular Degeneration
Award Amount:
$100,000
Grant Reference ID:
M2004042
Award Type:
Standard
Award Region:
US Northwestern

A Genetic Model for Age-Related Cone Degeneration

Summary

These experiments use a new animal model, zebrafish, to obtain a better understanding of the genetics of age-related photoreceptor loss and to test new potential therapies.

Details

Age-related macular degeneration (AMD) is a progressive disease that causes blindness. This disease affects the retinal pigmented epithelium (RPE) cells and photoreceptor (light-sensitive) cells, resulting in loss of vision. There is currently no cure. The causes are unclear and difficult to determine due to complexities in genetics related to the disorder and paucity of animal models. We have recently observed that the cone photoreceptors degenerate in aging zebrafish carrying a deletion allele for a known gene. This gene encodes a signaling protein that is secreted by the RPE and supports the development of photoreceptors. Together these data suggest that the heterozygous condition for this deletion may provide a genetic model for age-related photoreceptor degeneration. The long-term goal of this project is to use these zebrafish to obtain a better understanding of age-related photoreceptor loss and to test new therapies. More ambitiously, the project seeks to use this model of the disease to help identify underlying genetic causes of AMD. The Zebrafish model offers tremendous potential for the study of photoreceptor degeneration related to age, as well as mechanisms for cone replacement.

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