Clinical Trials for AMD: A BrightFocus Interview with Benjamin Kim, MD

Clinical trials are extremely important for evidence-based medicine. Benjamin Kim
Learn about a clinical trial that may slow the progression of advanced dry age-related macular degeneration.

A clinical trial at the University of Pennsylvania, supported by BrightFocus’ Macular Degeneration Research program, is testing whether alpha lipoic acid can slow down the growth of geographic atrophy, an advanced form of dry age-related macular degeneration.

BrightFocus: What does your clinical trial do?

Dr. Kim: The atrophy (death of retinal tissue) that develops in advanced age-related macular degeneration (AMD) causes approximately 20% of the legal blindness in the United States, and there is no available treatment. The GALA (Geographic Atrophy Lipoic Acid) trial is testing if alpha lipoic acid can slow down the growth of this atrophy. Alpha lipoic acid is an oral supplement that is a potent antioxidant and iron-chelator; it can prevent the damaging effects of oxidative stress and iron overload in AMD.

BrightFocus: Why are clinical trials important?

Dr. Kim: Clinical trials are tremendously important for evidence-based medicine. Physicians need high quality data to be confident that a recommended treatment will help patients and not have concerning side effects. This can only be achieved through carefully designed clinical trials.

BrightFocus: What advice would you give to someone considering volunteering for a clinical trial?

Dr. Kim: If you have any interest in a clinical trial, I recommend being proactive and discussing this with your physician. Depending on the disease, there sometimes are several different clinical trials at different stages of development. Ultimately, each participant has to weigh their own potential risks and benefits and discuss with their physician to make the best decision about trial participation.

BrightFocus: Is there a misperception that the public has about clinical trials that you would like to correct?

Dr. Kim: While many people do appreciate the importance of clinical trials, some may have apprehension about participating in a clinical trial. However, trials are rigorously designed to maximize patient safety and monitor for any safety issues that could develop. Additionally, we must also remember that many FDA approved therapies that we use are available to us only because there were people that previously participated in trials.

BrightFocus: Are you hopeful for the future of vision research?

Dr. Kim: I’m very hopeful for the future of vision research. There have been astounding developments in ophthalmology. Scientists, study participants, and funding organizations like BrightFocus are really making a difference.

GALA Trial Information:

  • If you are a patient with geographic atrophy and would like to learn more about the GALA Trial, please contact Joan DuPont at 215-662-8038.


Search for Clinical Trials using Antidote:

Antidote is a third-party application that allows you to search for clinical trials. It is not affiliated with, or endorsed by, the BrightFocus Foundation or our website. Please see our disclaimer related to third-party sites for more information.

This series of articles promoting awareness of clinical trials is supported in part by an educational sponsorship from Biogen. BrightFocus is solely responsible for the content of this article.

This content was first posted on: January 19, 2018

The information provided here is a public service of the BrightFocus Foundation and should not in any way substitute for personalized advice of a qualified healthcare professional; it is not intended to constitute medical advice. Please consult your physician for personalized medical advice. BrightFocus Foundation does not endorse any medical product, therapy, or resources mentioned or listed in this article. All medications and supplements should only be taken under medical supervision. Also, although we make every effort to keep the medical information on our website updated, we cannot guarantee that the posted information reflects the most up-to-date research.

These articles do not imply an endorsement of BrightFocus by the author or their institution, nor do they imply an endorsement of the institution or author by BrightFocus.

Some of the content may be adapted from other sources, which will be clearly identified within the article.

More Like This

  • A view inside the eye showing floaters. Copyright 2019 Rendia, Inc

    What Causes Eye Floaters?

    Many people see some floaters in their vision and wonder whether they should be concerned. Learn what floaters are, what causes them, and when an eye doctor should be consulted.

    June 2, 2020
  • A yellow caution sign against a blue sky with  white clouds

    How to Recognize Vision Health Scams

    Learn the best way to avoid treatments that have limited or non-existent data to support their effectiveness for age-related macular degeneration (AMD).

    May 5, 2020
  • Photo of an eye of a person with macular degeneration

    Macular Degeneration & Coronavirus: Tips for Patients

    People with age-related macular degeneration (AMD) are also in the age group at higher risk for more severe coronavirus infections. It is important to know how to both protect your eyesight and at the same time stay safe from this virus.

    April 1, 2020
Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.