Kathryn Bowles, PhD

I am a postdoctoral fellow with six years’ experience researching neurodegenerative diseases using a range of cellular, molecular and genetic approaches. Following completion of my undergraduate degree in psychology and cognitive neuroscience at the University of Nottingham, UK, I went on to win a Wellcome Trust PhD studentship for the Integrative Neuroscience program at Cardiff University, UK. My PhD research focused on the dysregulation of kinase signaling in Huntington's disease, and how this may alter the subcellular localization of the protein Huntingtin. Following completion of my PhD in 2013, I won a seed fund award from the European Huntington's Disease Network to investigate the role of SMAD transcription factors in the context of Huntington's disease. For the past 2 years, I have been working as a postdoctoral fellow in Dr. Alison Goate's laboratory at the Icahn School of Medicine at Mount Sinai, New York, NY. My research uses computational, genetic and molecular techniques to understand the regulation of tau genetics and splicing in human tissues and in induced pluripotent stem cell (iPSC)-derived cell lines (ie, cells regenerated using tissue samples from living adults). I am interested in the normal regulation of tau expression, and how this associates with and differs among multiple tauopathies.