John
Crary

Dr. Crary is an experimental neurobiologist and board-certified neuropathologist. Dr. Crary has made substantial contributions to the way human brain diseases are diagnosed through an international network of neuropathologists, defining numerous neuropathological diagnostic categories. He spearheaded an international effort to establish consensus criteria for primary age-related tauopathy (PART). He has also contributed to efforts to define consensus criteria for aging-related tau astrogliopathy, chronic traumatic encephalopathy, and progressive supranuclear palsy. He is pioneering computer vision approaches (e.g., deep machine learning) to modernize the histopathological evaluation of brain tissues. Further, he leads independent basic studies probing fundamental mechanisms of neurodegeneration, mechanistically characterizing these changes with animal and cellular models, with a goal of bringing these insights back to clinical practice. Notably, he has led and contributed to numerous genetic and cellular studies examining the toxicity and regulation of expression of tau using novel animal and iPSC-derived models.