Ann-CharlotteGranholm-Bentley
PhD, DDS
Location
Aurora, CO, USA
Current Organization
University of Colorado
Biography
All investigators involved in this project have significant experience in the Down syndrome and Alzheimer fields.
Ann-Charlotte “Lotta” Granholm-Bentley, PhD, DDS, is the executive director of the Knoebel Institute for Healthy Aging at University of Denver (DU). She has a broad background in neurodegenerative disease, especially as it pertains to Down syndrome (DS), Alzheimer’s disease (AD) and aging. She has been funded by the NIH for 25 years and has more than 160 peer-reviewed articles, most of them related to aging, neurodegeneration, or behavioral alterations associated with aging, including both cognitive and motor domains of function. Dr. Granholm was the director of the Brain Bank at the Medical University of South Carolina (MUSC) for 15 years, and is now the inaugural Executive Director for the Knoebel Institute for Healthy Aging at DU since 2016. Dr. Granholm’s laboratory is highly focused on exosome work, both in mouse models and humans. Dr. Granholm recently published the first study on AD biomarkers in exosomes from patients with DS-related AD and controls, demonstrating that AD biomarkers are present early in life in those with DS. This was a collaborative study, co-authored by Dr. Mufson (below) and several collaborative partners.
News Featuring This Grantee
Research News
Tau Toxicity – New Insights from Down Syndrome-Related Alzheimer’s Disease
Research finds that extracellular vesicles derived from the blood of people with Down syndrome and Alzheimer’s disease can spread tau misfolding in normal mice.
Research News
Denver Alzheimer’s Researcher Plays Key Role in Colorado COVID-19 Response
Alzheimer’s researcher, Lotta Granholm-Bentley, PhD, DDS, is playing a key role in her community’s medical response to the coronavirus, and working with seniors to help combat the sense of isolation many are feeling.