Treating Memory Loss in Alzheimer's Disease by Strengthening Synapses

About the Research Project
Program
Award Type
Standard
Award Amount
$300,000
Active Dates
July 01, 2019 - March 31, 2023
Grant ID
A2019586S
Goals
People with Alzheimer’s disease lose the ability to remember things, especially things they recently learned. We recently discovered that mice missing a specific molecule called Synaptotagmin3, have better memory than normal mice. We now want to test if removing this molecule from mice with Alzheimer’s disease will improve their memory. If this works, it could be a way to treat humans with Alzheimer’s disease to improve their memory.
Summary
People with Alzheimer’s disease lose the ability to remember things, especially things they recently learned. We recently discovered that mice missing a specific molecule called Synaptotagmin3, have better memory than normal mice. We now want to test if removing this molecule from mice with Alzheimer’s disease will improve their memory. If this works, it could be a way to treat humans with Alzheimer’s disease to improve their memory.
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