The Role of Centaurin-α1 in Alzheimer’s Disease Pathology

It is thought that Alzheimer’s disease is caused by accumulation of ß-Amyloid. We recently identified that a signaling protein called centaurin-a1 (CentA1) causes ß-Amyloid-induced dysfunction of neurons and thus potentially contributes to brain dysfunction in Alzheimer’s disease. In this project, we will further study the potential roles of CentA1 in Alzheimer’s disease using newly developed CentA1 knockout mice in combination with the model mice for Alzheimer’s disease. We hope that this will lead to new therapeutics targeting CentA1.