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Grants > Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model Updated On: Feb. 5, 2025
Alzheimer's Disease Research Grant

Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model

Principal Investigator

Mallar Chakravarty, PhD

Douglas Research Centre

Montreal, Québec, Canada

About the Research Project

Program

Alzheimer's Disease Research

Award Type

Standard

Award Amount

$85,000

Active Dates

January 01, 2025 - December 31, 2026

Grant ID

CA2025002

Acknowledgement

This grant was funded through the Cross Border Grant Program in partnership with Alzheimer Nederland.

Goals

Sleep disruptions impact males and females differently in later life and are a known risk factor for Alzheimer’s disease.

Unique and Innovative

We believe that the longitudinal methodologies that we are using that allow us to track whole brain phenotypes using magnetic resonance imaging is extremely novel. Further, sex as a biological variable is typically completely overlooked in the context of preclinical work, thus modelling female-specific risk factors for the disease may provide important knowledge that may allow us to move towards precision medicine approaches.

Foreseeable Benefits

There is an overwhelming need to improve our understanding of female health in the context of neurodegenerative disorders. Understanding how sleep disturbance acts as a risk factor for Alzheimer’s diease and how the impact of this biological phenomenon may impact brain health is critical to developing interventions that may act on this important part of daily life.