Regulation Of Tau Homeostasis By Molecular Chaperones

Jason Gestwicki, PhD University of California, San Francisco


Alzheimer’s disease is a devastating condition that impacts patients, their families and their caregivers. Since there is little in the way of treatment and as yet no cure for this disease, a major goal of our group is to pursue new and unconventional ways of preventing it. In the current project, we are trying to understand how the body’s own proteins (termed molecular chaperones) protect us against Alzheimer’s disease. At the same time, we hope to learn why this system fails during disease, so we can use this knowledge to design drugs that activate the molecular chaperones.