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Grants > Proteomics of the Oxidative Phosphorylation System in AD Updated On: Jan. 19, 2025
Alzheimer's Disease Research Grant

Proteomics of the Oxidative Phosphorylation System in AD

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Principal Investigator

Gail Breen, PhD

The University of Texas at Dallas

Dallas, TX, USA

About the Research Project

Program

Alzheimer's Disease Research

Award Type

Standard

Award Amount

$100,000

Active Dates

April 01, 2005 - March 31, 2008

Grant ID

A2005271

Summary

A reduced rate of brain metabolism is one of the best documented abnormalities in Alzheimer’s disease (AD). Since abnormalities in mitochondrial energy production appear to play a major role in pathophysiology of AD, Dr. Breen plans to test the hypothesis that the proteins of the mitochondrial oxidative phosphorylation system are decreased or modified in the brains of AD patients. If data using a mouse model of AD demonstrate differences in the levels of the proteins of the oxidative phosphorylation system in AD versus control brains, then future studies will be directed towards examining these proteins in human AD brains. Identification of the factors involved in the etiology and/or progression of AD may lead to the development of treatments to improve neuropsychological function in AD patients or delay the onset of the disease.