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Grants > Oxidative Mechanisms of Amyloid Initiation Updated On: Jan. 19, 2025
Alzheimer's Disease Research Grant

Oxidative Mechanisms of Amyloid Initiation

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Principal Investigator

Ian Murray, PhD

University of Pennsylvania

Bentonville, AR, USA

About the Research Project

Program

Alzheimer's Disease Research

Award Type

Standard

Award Amount

$100,000

Active Dates

April 01, 2004 - March 31, 2006

Grant ID

A2004248

Summary

Patients with Alzheimer’s disease experience a gradual loss of memory, problems with reasoning, disorientation, loss of language skills, and behavioral problems. The major cause of the disease is thought to be the misfolding of a specific protein within the brain. Many researchers hypothesize that oxidation and free radical damage to the brain predates the protein misfolding and the clumping of protein fragments into plaques. Dr. Murray is investigating the interactions of oxidation and free radical damage with the brain lipids and misfolded proteins. It is hoped that the resulting knowledge will assist in the development of new treatment methods for Alzheimer’s and possibly other neurodegenerative diseases.