Oxidative Lipid Degradation in Alzheimer's Disease

Paul Axelsen, MD University of Pennsylvania


Oxidative stress will be examined in animal models of Alzheimer's disease using novel radiolabeled compounds that are designed to reveal how the proteins that accumulate in Alzheimer's disease are induced to form fibrils and plaques.

Project Details

We all need oxygen to survive, but oxygen can react with chemicals in the body to create harmful byproducts and “oxidative stress.” Dr. Paul Axelsen and colleagues will study the role of oxidative stress in Alzheimer's disease. They will attempt to determine how oxidative stress causes chemical changes in dietary fats (including omega‐3 and omega‐6) that can damage brain amyloid proteins. These researchers will use special tracers on the fats to detect the changes in dietary fats and in the amyloid proteins of mouse models of Alzheimer's disease and oxidative stress. The results from this study may give ideas on how to fight oxidative stress in the human brain.