Next-Generation Glaucoma Drugs to Selectively Release the Pressure-Building Block in Schlemm’s Canal

Summary

We now understand that endothelial cells of the inner wall of Schlemm’s canal (SC) play a key role in homeostatic control mechanisms that maintain IOP within a target range. The long-term goal of this project is to develop novel therapies that directly target SC cells to improve IOP control. These targeted therapies will be highly effective due their specificity, and will thus greatly benefit glaucoma patients.