LOU Rat as a Model of Cognitive Resilience in Alzheimer’s Disease

Marianne Leger, PhD Caen-Normandy University, Caen, France


This project will aim to model cognitive resilience in rodents by combining a rat model of successful aging with a model of early Alzheimer’s disease (AD). The hypothesis tests whether these rats are resilient to AD pathology, resulting in intact cognition compared to AD rats. The involvement of the serotonergic system will be evaluated to determine potential therapeutic targets that may promote resilience to AD.