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Grants > In Vivo Dynamic of Amyloid Induced Dystrophic Neurites Updated On: Jan. 19, 2025
Alzheimer's Disease Research Grant

In Vivo Dynamic of Amyloid Induced Dystrophic Neurites

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Principal Investigator

Robert Brendza, PhD

Washington University in St. Louis

St. Louis, MO, USA

About the Research Project

Program

Alzheimer's Disease Research

Award Type

Standard

Award Amount

$100,000

Active Dates

April 01, 2004 - March 31, 2006

Grant ID

A2004240

Summary

In AD, the appearance of dystrophic or degenerating neuritis, which are thought to disrupt neuronal function, correlates with the clinical severity of dementia. However, it remains unknown whether the damage to these neuronal structures is static, dynamic or possibly reversible. Dr. Brendza is analyzing neuritic plaques in the brains of living transgenic mice that develop amyloid plaques and AD-like pathology. Amyloid-associated dystrophic neurites, as well as unaffected neuron structures, can be visualized in these animals by their inherent fluorescence. Dr. Brendza is using this system to investigate whether dystrophic neurites undergo dynamic changes over time and to determine if treatments that remove amyloid will reverse the neuronal damage. It is hoped that this research will yield new insight into the dynamic nature of amyloid toxicity and help scientists understand whether removing existing amyloid or sequestering diffusible toxic forms of amyloid-beta peptide is a valid target for the treatment of Alzheimer’s disease.