Identify Genes Responsible for AD Neuron Vulnerability

About the Research Project
Program
Award Type
Standard
Award Amount
$300,000
Active Dates
April 01, 2005 - March 31, 2008
Grant ID
A2005070
Summary
The identities of “AD genes” are largely unknown. Identification of these genes is one of the most challenging tasks neuroscientists need to address in order to understand the mechanisms underlying the genesis of AD and to find a cure for it. To identify these genes, laboratories have adopted a new technology called “microarray” to compare the gene expression patterns. Searching for the genes expressed differentially in certain types of neuron cells, requires use of a newly developed technology called Laser Capture Microdissection (LCM), to isolate individual types of neurons in the brain region that controls cognitive activity. Dr. Xu plans to identify the genes that govern AD susceptibility at a cellular level by using LCM together with microarray analyses. The potential results of this research will enhance our understanding of the molecular mechanisms underlying pathogenesis of AD and provide crucial information for developing effective therapies.
Grants
Related Grants
Alzheimer's Disease Research
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015
Principal Investigator
Guojun Bu, PhD
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015

Principal Investigator
Guojun Bu, PhD
Alzheimer's Disease Research
Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Mallar Chakravarty, PhD
Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Mallar Chakravarty, PhD
Alzheimer's Disease Research
Regulatory Mechanisms Underlying Endosomal Targeting of SORL1
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Olav Andersen, PhD
Regulatory Mechanisms Underlying Endosomal Targeting of SORL1
Active Dates
January 01, 2025 - December 31, 2026

Principal Investigator
Olav Andersen, PhD