Genetic Modifiers of Presenilin

About the Research Project
Program
Award Type
Standard
Award Amount
$200,000
Active Dates
April 01, 1999 - March 31, 2001
Grant ID
A1999004
Summary
This project is aimed at the identification of genes that may modify the susceptibility to, or severity of, Alzheimer’s disease. The model organism Drosophila (the fruit fly) is being used to perform a screen for genes that interact genetically with the Drosophila presenilin gene. Dr. Boulianne is also screening for proteins that physically interact directly with presenilin. Candidate genes identified through these approaches will be evaluated in transgenic mice for their ability to contribute to the development of an Alzheimer’s disease phenotype. The results of this study could further the goal of creating a more useful animal model for the discovery of additional Alzheimer’s-related genes.
Grants
Related Grants
Alzheimer's Disease Research
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015
Principal Investigator
Guojun Bu, PhD
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015

Principal Investigator
Guojun Bu, PhD
Alzheimer's Disease Research
Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Mallar Chakravarty, PhD
Synergistic Effects of Biological Sex and Sleep Loss in an AD Mouse Model
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Mallar Chakravarty, PhD
Alzheimer's Disease Research
Regulatory Mechanisms Underlying Endosomal Targeting of SORL1
Active Dates
January 01, 2025 - December 31, 2026
Principal Investigator
Olav Andersen, PhD
Regulatory Mechanisms Underlying Endosomal Targeting of SORL1
Active Dates
January 01, 2025 - December 31, 2026

Principal Investigator
Olav Andersen, PhD