APPBP1, the Cell Cycle and Alzheimer's Disease

About the Research Project
Program
Award Type
Standard
Award Amount
$100,000
Active Dates
April 01, 2002 - March 31, 2004
Grant ID
A2002219
Summary
There is increasing evidence that neurons in Alzheimer’s disease (AD) enter the cell cycle (a period of DNA replication leading up to cell division), but because they are locked into a non-dividing state, the attempt to divide causes them to die. Work from many investigators suggests that the amyloid precursor protein (APP) is a signaling molecule whose function may be to regulate cell death. Dr. Chen has found a cell cycle protein called APP-BP1 that binds to APP, and its over-expression in neurons leads to cell death. The present work is based on the hypothesis that AD results from a gradual dysfunction of the APP interaction with APP-BP1, and this dysfunction leads to neuronal death by the abnormal signaling through APP. Dr. Chen will examine the properties of APP and APP-BP1 to identify the protein domains and their function; he will determine where these proteins are located within the cells; he will over-express the proteins in neurons in culture to determine their function; and he will determine if other proteins bind to APP-BP1 and play a role in AD. The data obtained from these studies will help to understand the normal function of APP and AP-BP1 in the brain and identify how these proteins may malfunction in AD resulting in cell death.
Grants
Related Grants
Alzheimer's Disease Research
Tau, Aβ, and Network Degeneration in Alzheimer’s Disease
Active Dates
July 01, 2014 - June 30, 2017
Principal Investigator
Rik Ossenkoppele, PhD
Tau, Aβ, and Network Degeneration in Alzheimer’s Disease
Active Dates
July 01, 2014 - June 30, 2017

Principal Investigator
Rik Ossenkoppele, PhD
Alzheimer's Disease Research
Fingerprinting In Vivo and In Vitro Prion Strains
Active Dates
September 01, 2020 - November 30, 2022
Principal Investigator
Hyunjun Yang, PhD
Fingerprinting In Vivo and In Vitro Prion Strains
Active Dates
September 01, 2020 - November 30, 2022

Principal Investigator
Hyunjun Yang, PhD
Alzheimer's Disease Research
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015
Principal Investigator
Guojun Bu, PhD
Partnership with Molecular Neurodegeneration Open Access Journal
Active Dates
July 01, 2010 - June 30, 2015

Principal Investigator
Guojun Bu, PhD