Grants > Alzheimer's Disease, Before Plaques and Tangles Updated On: Jun 17, 2025

Alzheimer's Disease Research Grant

Alzheimer's Disease, Before Plaques and Tangles

Translational Research & Clinical Interventions

Principal Investigator

Juan Troncoso, MD

Johns Hopkins University

Baltimore, MD, USA

About the Research Project

Program

Alzheimer's Disease Research

Award Type

Standard

Award Amount

$250,000

Active Dates

July 01, 2015 - June 30, 2018

Grant ID

A2015332S

Acknowledgement

This grant is made possible by a bequest from the Howlett Revocable Trust.

Co-Principal Investigator(s)

Lee Martin, PhD, Johns Hopkins University

Summary

In this application, we propose to study the postmortem brain of individuals between 30 and 50 years of age and to identify those brains with the very early pathologic changes or lesions of Alzheimer’s disease. Then, we will study whether these lesions are associated with other abnormalities and whether they cause degeneration and death of brain nerve cells. Information obtained from this study could eventually help the development of new diagnostic tests and treatments for Alzheimer’s disease.

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