A New Method to Determine Alzheimer's and Parkinson's Toxins in the Lipid-Riched Environment

About the Research Project
Program
Award Type
Standard
Award Amount
$100,000
Active Dates
September 01, 2020 - August 31, 2022
Grant ID
A20201759S
Goals
In diseases such as Alzheimer’s and Parkinson’s, toxic protein lumps form holes in them nerve cells. I want to discover how those lumps assemble at atomic resolution.
Summary
In Alzheimer’s disease, Aβ peptides form toxic and transient oligomers, leading to cellular membrane leakage and then neuronal cell death. We aim to stabilize the transient oligomers on a functionally relevant α-hemolysin (αHL) scaffold and confine the stabilized/hybridized oligomers for crystallization in the lipidic cubic phase system followed by X-ray structure determination. The hybridized Aβ oligomers will allow studying many of the features of amyloid oligomers that can not be characterized due to the transient and heterogeneity of wild-type Aβ oligomers. Our work will yield essential insight into the mechanism of its neurotoxicity.
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