Telomere Lengths in POAG Trabecular Meshwork Cells

E. Timothy O'Brien, PhD
Duke University Medical Center (Durham, NC)
Year Awarded:
2000
Grant Duration:
April 1, 2000 to March 31, 2001
Disease:
Glaucoma
Award Amount:
$25,000
Grant Reference ID:
G2000020
Award Type:
Standard
Award Region:
US Southeastern

Telomere Lengths in POAG Trabecular Meshwork Cells

Details

The ends of chromosomes, called telomeres, shorten each time that most cells in the body divide. When telomeres become too short, cells can no longer divide and eventually die. Dr. O'Brien has uncovered evidence that trabecular meshwork cells from eyes with primary open angle glaucoma (POAG) undergo fewer cell divisions in culture than normal TM cells. He is exploring the possibility that these cells have shorter telomeres and therefore a decreased proliferative capacity. If telomere length is found to be decreased in POAG TM cultures, Dr. O'Brien will attempt to introduce the gene required for telomere maintenance (telomerase) to determine if he can restore proliferative capacity. If the TM cells can be preserved in this way, this research could lead to new treatments for glaucoma patients.
Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.