Role of Glial Cells in Retinal Ganglion Cell Death

Theresa Good, PhD
Texas Engineering Experiment Statio (College Station, TX)
Year Awarded:
1999
Grant Duration:
April 1, 1999 to March 31, 2001
Disease:
Glaucoma
Award Amount:
$50,000
Grant Reference ID:
G1999009
Award Type:
Standard
Award Region:
US Southern

Role of Glial Cells in Retinal Ganglion Cell Death

Details

One hypothesis for how intraocular pressure leads to vision loss is that the cell damage is the result of increased mechanical forces. Dr. Good has proposed that glial cells within the retina contribute to optic nerve damage by producing toxic molecules (nitric oxide and glutamate). She is testing this hypothesis with an in vitro model of shear stress and strain, where retinal glial cells are deformed to mimic the stress that occurs in living eyes and then measuring the production of toxic compounds. Through these measurements, she hopes to identify factors that contribute to retinal ganglion cell death. The ultimate goal of this research is to develop new therapeutic approaches to treating glaucoma.
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