Biomarkers for Glaucoma

John W. Crabb, PhD
The Cleveland Clinic Foundation (Cleveland, OH)
Year Awarded:
Grant Duration:
July 1, 2015 to June 30, 2017
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Midwestern
 John W. Crabb, PhD

Proteomic Approaches to Primary Open Angle Glaucoma Mechanisms and Biomarkers


Glaucoma is an age-related ocular disease and leading cause of blindness. While age and intraocular pressure (IOP) are major risk factors for the development of primary open angle glaucoma (POAG), eye doctors cannot yet predict who will develop POAG.  The identification of additional risk factors is a high priority.  The proposed research will identify glaucoma-altered proteins in aqueous humor, the clear fluid at the front of the eye, in order to clarify disease mechanisms and help identify of biomarkers that will assist in caring for glaucoma patients.

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