Proteomic Approaches to Primary Open Angle Glaucoma Mechanisms and Biomarkers

John W. Crabb, PhD The Cleveland Clinic Foundation


Glaucoma is an age-related ocular disease and leading cause of blindness. While age and intraocular pressure (IOP) are major risk factors for the development of primary open angle glaucoma (POAG), eye doctors cannot yet predict who will develop POAG.  The identification of additional risk factors is a high priority.  The proposed research will identify glaucoma-altered proteins in aqueous humor, the clear fluid at the front of the eye, in order to clarify disease mechanisms and help identify of biomarkers that will assist in caring for glaucoma patients.