Neurotrophic Biofactories for the Treatment of Glaucoma
Dr. Demetriades’ team will use a gene therapy approach to deliver neuroprotective proteins to specific cells within the retina. Retinal ganglion cell (RGC) death is the hallmark of glaucoma. The gene therapy method will deliver therapeutic proteins to RGCs and adjacent cells within the retina to improve their survival.
The innovative aspect of this proposal is the use of a cell-specific gene therapy approach. Dr. Demetriades will develop gene therapy carrier systems that enable delivery of a therapeutic protein to a specific cell type within the retina. This research could lead to the creation of a novel delivery system for the eye.
Current treatments control eye pressure but vision loss may still occur. Dr. Demetriades’ study will provide new insights into the potential of cell-specific gene therapy for the treatment of glaucoma. Their goal through this work is to develop an adjuvant therapy that slows or stops disease progression in order to prevent vision loss.
First published on: July 1, 2013
Last modified on: June 20, 2013