Remodelling connective tissue near the optic nerve

Colm O'Brien, MD, FRCS
Mater Misericordiae Hospital (Dublin, Ireland)
Year Awarded:
2007
Grant Duration:
April 1, 2007 to March 31, 2009
Disease:
Glaucoma
Award Amount:
$90,000
Grant Reference ID:
G2007051
Award Type:
Standard
Award Region:
International

Modulation of Lamina Cribrosa Matrix Remodeling in POAG

Summary

This project intends to test the hypothesis of that the use of novel anti-fibrotic therapies will reduce the damage done in glaucoma to the retinal ganglion cells thereby alleviating the resultant loss of vision.

Details


This project intends to test the hypothesis of that the use of novel anti-fibrotic therapies will reduce the damage done in glaucoma to the retinal ganglion cells thereby alleviating the resultant loss of vision. At present glaucoma represents the most common form of irreversible blindness in the western world. The exact causes of the different types of glaucoma are not fully understood but in one common form, primary open angle glaucoma it is believed that mechanical strain induced by elevated intra-occular pressure plays a part. This causes changes in the connective tissue of the lamina cribrosa, which is where the optic nerves exit the eye. Previous evidence has shown that soluble growth factors such as the TGF- family can affect the extracellular composition of this tissue. By modulating the expression of the TGF- family we hope to change the connective tissue composition of the lamina cribrosa and thereby reduce the damage to the retinal ganglion cells and reduce loss of visual function.

Publications

Walshe, T.E., Ferguson, G., Connell, P., O'Brien, C., and Cahill, P.A. (2005) Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculature. Investigative Ophthalmology &Visual Science. 46(1):375-382.  
 

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