Microglia/Macrophages and neuroprotection in Glaucoma

Raymond Chang, PhD
University of HonKong (HongKong, China)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Glaucoma
Award Amount:
$90,000
Grant Reference ID:
G2005001
Award Type:
Standard
Award Region:
International

Microglia/Macrophages and neuroprotection in Glaucoma

Details


Glaucoma is a chronic disease in which the neurons, called retinal ganglion cells, undergo degeneration. Another trait of developing glaucoma is an increase of pressure within the eyes. Recently, a novel approach was proposed to utilize our body immunity to protect neurons in the eyes. Dr. Chang's study aims to define which factors or what conditions for the activation of innate immune cells can lead these cells to elicit protective effects. He will also study how a Chinese medicine, Chinese Wolfberry, exhibits protective effects to neurons in the eyes via mild activation of innate immune cells. Knowledge of how body immunity exerts protective effects to neurons in the eyes will hopefully pave a new road for therapeutic intervention against loss of vision in glaucoma.

Publications

Chan, H.C., Chang, R.C., Koon-Ching Ip A., Chiu, K., Yuen, W.H., Zee, S.Y., So, K.F. (2007) Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Exp Neurol. 203(1):269-273.  

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