Mechanism of Optic Nerve Damage and Neuroprotection

Naren Banik, PhD
Medical University of South Carolin (Charleston, SC)
Year Awarded:
1998
Grant Duration:
April 1, 1998 to March 31, 2000
Disease:
Glaucoma
Award Amount:
$50,000
Grant Reference ID:
G1998411
Award Type:
Standard
Award Region:
US Southeastern

Mechanism of Optic Nerve Damage and Neuroprotection

Details


Publications

Ray, S.K., Fedan, M., Nowak, M., Wilford, G.G., Hogan, E.L., and Banik, N.L. (2000) Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res. 852(2):326-334.  

[Book Chapter] Banik, N.L. and Hogan, EL. The Biology of Myelination in the Vertebrate Nervous System. In: Principles of Medical Biology (Bittar EE, Bittar N, eds) JAI Press 2000.

[Book Chapter] Banik, N.L. and Hogan, E.L. The Biology of Demyelination: Mechanisms of Myelinolysis. In: Principles of Medical Biology (Bittar EE, Bittar N, eds). JAI Press 2000.

[Book Chapter] Lajtha, A. and Banik, N.L. Proteinases in the Central Nervous System. In: Critical Reviews in Neurobiology (Nelson JE, ed.) CRC Press 2000.

[Book Chapter] Shields, D.C., Smith, M.E., and Banik, N.L. Proteolysis and Pathophysiology of Demyelinating Disease. In: Proteolytic Enzymes in the Pathophysiology of Neurodegenerative Diseases (Banik NL, Lajtha A, eds). Plenum Press 2000.

Ray, S.K., Wilford, G.G., Matzelle, D.C., Hogan, E.L., and Banik, N.L. (1999) Calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury. Ann N Y Acad Sci. 890:261-269.  

Banik, N.L. and Shields, D.C. (1999) A putative role for calpain in demyelination associated with optic neuritis. Histol Histopathol. 14(2):649-656.  

Ray, S.K., Wilford, G.G., Crosby, C.V., Hogan, E.L., and Banik N.L. (1999) Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells. Brain Res. 829(1-2):18-27.  

Shields, D.C. and Banik, N.L. (1999) Pathophysiological role of calpain in experimental demyelination. J. Neurosc. Res. 55(5):533-541.  

Shields, D.C., Schaecher, K.E., Goust, J.M., and Banik, N.L. (1999) Calpain activity and expression are increased in splenic inflammatory cells associated with experimental allergic encephalomyelitis. J Neuroimmunol. 99(1):1-12.  

Shields, D.C., Schaecher, K.E., Saido, T.C., and Banik, N.L. (1999) A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci USA. 96(20):11486-11491.  

Shields, D.C. and Banik, N.L. (1998) Upregulation of calpain activity and expression in experimental allergic encephalomyelitis (EAE): a putative role for calpain in demyelination. Brain Res. 794(1):68-74.  

Shields, D.C. and Banik, N.L. (1998) Putative role of calpain in the pathophysiology of experimental optic neuritis. Exp Eye Res. 67(4):403-410.  

Shields, D.C., Ray, S.K., Gantt-Wilford, G., and Banik, N.L. (1998) Calpain expression varies among different rat and bovine central nervous system regions. J Neurosci Res. 53(4):482-489.  

Shields, D.C., Tyor, W.R., Deibler, G.E., and Banik, N.L. (1998) Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study. Brain Res. 784(1-2):299-304.  

Shields, D.C., Tyor, W.R., Deibler, G.E., Hogan, E.L., and Banik, N.L. (1998) Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proc Natl Acad Sci USA. 95(10):5768-5772.  

Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.